Biricodar

A pipecolinate derivative. Functioning as a modulator of P-glycoprotein (P-gp) and multidrug resistance protein (MRP-1), biricodar restores drug sensitivity to cells expressing P-glycoprotein and MRP1, the cellular efflux pumps that are the major causes in tumor cell resistance to chemotherapeutic agents. This agent binds directly to Pgp and MRP-1 and inhibits efflux pump activity, resulting in increased intracellular accumulation and retention of cytotoxic agents. (NCI Thesaurus)

YOU MAY ALSO LIKE

Bird Flu

Birds, just like people, get the flu. Bird flu viruses infect birds, including chickens, other poultry, and wild birds such as…

Bird Fancier's Lung

A respiratory disorder due to an acquired hypersensitivity to the dust of bird droppings.

BIRC7 wt Allele

Human BIRC7 wild-type allele is located in the vicinity of 20q13.3 and is approximately 5 kb in length. This allele, which encodes…

BIRC7 Gene

This gene regulates apoptosis through dual transcriptional activation pathways.

BIRC6 wt Allele

Human BIRC6 wild-type allele is located within 2p22-p21 and is approximately 261 kb in length. This allele, which encodes baculoviral IAP repeat-containing…

BIRC6 Gene

This gene regulates the apoptotic program via signal transduction in the ubiquitination pathway.