| Health / Medical Topics |
Biricodar Dicitrate
Definition 1
The dicitrate salt of a synthetic pipecolinate derivative with potential chemosensitizing activity. Biricodar binds directly to the plasma membrane drug-efflux pumps P-glycoprotein (P-gp) and multidrug resistance protein 1 (MRP-1) and inhibits their activities, which may result in increased intracellular accumulation and retention of cytotoxic agents. (NCI Thesaurus)
Definition 2
A drug being studied to make cancer cells less resistant to the effects of chemotherapy. (NCI Dictionary)
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