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Bisphosphonate-associated osteonecrosis
Pronunciation
Definition 1
The necrosis (death) of bone tissue caused by treatment with a bisphosphonate (a drug or substance used to treat osteoporosis, bone pain caused by some types of cancer, and high blood calcium). It commonly occurs in the jaw bones. There may be pain, swelling and infection in the areas of necrosis. Also called BON. (NCI Dictionary)
Definition 2
Necrosis of the mandible or maxilla in patients receiving intravenous or oral bisphosphonate therapy. It usually manifests with slow healing or failure to heal of a jaw bone following oral surgery. In a minority of cases, the necrosis appears spontaneously. Signs and symptoms include pain, swelling and infection of the affected area. (NCI Thesaurus)
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