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Bizelesin
Pronunciation
Definition 1
An anticancer drug that belongs to the family of drugs called alkylating agents. It is also an antitumor antibiotic. (NCI Dictionary)
Definition 2
A synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting DNA replication and RNA synthesis. Bizelesin also enhances p53 and p21 induction and triggers G2/M cell-cycle arrest, resulting in cell senescence without apoptosis. (NCI Thesaurus)
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