BRAF wt Allele

Human BRAF wild-type allele is located within 7q34 and is approximately 190 kb in length. This allele, which encodes B-Raf proto-oncogene serine/threonine-protein kinase protein, plays a role in the transduction of mitogenic signals from the cell membrane to the nucleus. A specific activating somatic mutation in the BRAF gene is associated with several types of cancer such as colorectal and thyroid carcinomas and malignant melanoma. (NCI Thesaurus)

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BRAF V600K Mutation Present

A molecular finding indicating the presence of a BRAF V600K mutation in a tissue sample.

BRAF V600K Mutation Analysis

A molecular diagnostic test performed to determine the presence or absence of a BRAF V600K mutation in a tissue sample.

BRAF V600E Mutation Present

A molecular finding indicating the presence of a BRAF V600E mutation in a tissue sample.

BRAF V600E Mutation Analysis

A molecular diagnostic test performed to determine the presence or absence of a BRAF V600E mutation in a tissue sample.

BRAF V600 Protein Variation

A change in the valine at position 600 of the serine/threonine-protein kinase B-raf protein to another amino acid.

BRAF V600 Mutation

An activated mutation in the BRAF gene involving an amino acid change at position 600.