Brain benefits of aerobic exercise lost to mercury exposure

NIH | SEPTEMBER 29, 2016

Cognitive function improves with aerobic exercise, but not for people exposed to high levels of mercury before birth.

Low mercury fish include salmon. Image credit: Blu3d/Wikipedia (CC BY-SA 3.0)

This is one of the first studies to examine how methylmercury exposure in the womb may affect cognitive function in adults.

Adults with high prenatal exposure to methylmercury, which mainly comes from maternal consumption of fish with high mercury levels, did not experience the faster cognitive processing and better short term memory benefits of exercise that were seen in those with low prenatal methylmercury exposures.

Mercury comes from industrial pollution in the air that falls into the water, where it turns into methylmercury and accumulates in fish.

The scientists, based at the Harvard T.H. Chan School of Public Health, suspect that prenatal exposure to methylmercury, known to have toxic effects on the developing brain and nervous system, may limit the ability of nervous system tissues to grow and develop in response to increased aerobic fitness.

The 197 study participants are from the Faroe Islands, 200 miles north of England, where fish is a major component of the diet.

At age 22, this subset of the original 1,022 participants took part in a follow-up exam that included estimating the participants’ VO2 max, or the rate at which they can use oxygen, which increases with aerobic fitness. Also, a range of cognitive tests were performed related to short-term memory, verbal comprehension and knowledge, psychomotor speed, visual processing, long-term storage and retrieval, and cognitive processing speed.

Overall, the researchers found that higher VO2 max values were associated with better neurocognitive function, as expected based on prior research. Cognitive efficiency, which included cognitive processing speed and short term memory, benefitted the most from increased VO2 max.

But when the researchers divided the participants into two groups based on the methylmercury levels in their mothers while they were pregnant, they found that these benefits were confined to the group with the lowest exposure.

The U.S. Food and Drug Administration recommends that children and women of childbearing age eat two to three weekly servings of fish low in mercury as part of a healthy diet.

Low mercury fish include salmon, shrimp, pollock, canned light tuna, tilapia, catfish, and cod. Four types of fish should be avoided because of typically high mercury levels — tilefish from the Gulf of Mexico, shark, swordfish, and king mackerel.

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