BTK Inhibitor ONO-4059

An orally available formulation containing an inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, ONO-4059 covalently binds to BTK within B cells, thereby preventing B cell receptor signaling and impeding B cell development. As a result, this agent may inhibit the proliferation of B cell malignancies. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival. (NCI Thesaurus)

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This gene is involved in both signaling and B-cell development.

BTG2 wt Allele

Human BTG2 wild-type allele is located in the vicinity of 1q32 and is approximately 4 kb in length. This allele, which encodes…

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This gene is involved in the regulation of the G1/S transition of the cell cycle.

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Human BTG1 wild-type allele is located in the vicinity of 12q22 and is approximately 3 kb in length. This allele, which encodes…