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Buccal Route of Administration
Definition 1
Administration of a substance through the mucosal membrane on the inside of the cheek or the back of the mouth. Buccal route bypasses first pass metabolism and avoids pre-systemic elimination in the gastrointestinal tract. The buccal environment is well supplied with both vascular and lymphatic drainage and is well suited for a retentive device. This is a feasible alternative for systemic delivery of orally inefficient drugs, such as peptide and protein drug molecules. (NCI Thesaurus)
Definition 2
Administration directed toward the cheek, generally from within the mouth. (Food and Drug Administration/CDISC)
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