Bupropion hydrochloride

Pronunciation

Definition 1

A drug used to treat depression and certain other disorders. It is also used to help people stop smoking. Bupropion hydrochloride increases the levels of the chemicals dopamine, serotonin, and norepinephrine in the brain. This helps improve mood and can lessen cravings for nicotine. It is a type of antidepressant and a type of nicotine receptor antagonist. Also called Wellbutrin and Zyban. (NCI Dictionary)

Definition 2

The hydrochloride salt of an aminoketone antidepressant. The molecular mechanism of the antidepressant effect of bupropion is unknown. This agent does not inhibit monoamine oxidase and, compared to classical tricyclic antidepressants, is a weak blocker of the neuronal uptake of serotonin and norepinephrine. Buproprion also weakly inhibits the neuronal re-uptake of dopamine. (NCI Thesaurus)

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