| Health / Medical Topics |
Calcium-Binding Domain
Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both side by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1, 3, 5, 7, 9 and 12; these residues are denoted by X, Y, Z, -Y, -X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand). (From InterPro IPR002048) (NCI Thesaurus)
YOU MAY ALSO LIKE
Calcium-activated potassium channel subunit alpha-1 (1236 aa, ~138 kDa) is encoded by the human KCNMA1 gene. This protein plays a role in…
Encoded by human CLCA2 Gene (similar to CLCA1), the 943-amino acid Calcium-Activated Chloride Channel-2 (CLCA Family) is expressed in trachea, lung, and…
An orally bioavailable aqueous solution containing the chloride salt of the radioisotope calcium-46 (46Ca) with phosphate-binding and radioisotopic activities. Upon administration of…
A substance used to study the turnover of bone tissue in certain diseases, such as osteoporosis or cancer that has spread to…
An orally bioavailable aqueous solution containing the chloride salt of the radioisotope calcium-41 (41Ca) with phosphate-binding and radioisotopic activities. Upon administration of…
A substance used to diagnose and monitor cancer that has spread to the bones. It is also used to study the turnover…
