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Camptothecin
Pronunciation
Definition 1
An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors. (NCI Dictionary)
Definition 2
An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. (NCI Thesaurus)
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