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Canfosfamide Hydrochloride
Definition 1
The hydrochloride salt of a modified glutathione analogue with potential antineoplastic activity. Canfosfamide is selectively activated by glutathione S-transferase P1-1 into an alkylating metabolite that forms covalent linkages with nucleophilic centers in tumor cell DNA, which may induce a cellular stress response and cytotoxicity, and decrease tumor proliferation. S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies. (NCI Thesaurus)
Definition 2
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called glutathione analogs. (NCI Dictionary)
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