Carbon C 14 Oxaliplatin

A radioconjugate composed of the platinum agent oxaliplatin labeled with the isotope carbon C 14, that can be used to predict the response to oxaliplatin therapy using accelerator mass spectrometry (AMS). Upon intravenous administration of a microdose of carbon C 14 oxaliplatin, the oxaliplatin moiety covalently links to DNA and forms mono- and di-DNA adducts. The platinum-DNA adduct formation can be measured through quantification of C14-labeled drug-DNA adducts by using AMS. By measuring the microdose-induced DNA damage, the response to oxaliplatin-based chemotherapy can be assessed and predicted. Measurements that indicate either low drug-DNA adduct formation or increased DNA repair (C14 removal from DNA) are correlated with increased resistance to platinum-based chemotherapeutics. (NCI Thesaurus)

YOU MAY ALSO LIKE

Carbon C 14 Ombrabulin

A synthetic water-soluble analogue of combretastatin A4, derived from the South African willow bush (Combretum caffrum), labeled with carbon C 14 with…

Carbon C 14 Eribulin Acetate

A radioconjugate containing the acetate salt of eribulin, labeled with the beta particle-emitting radioisotope carbon C 14, with radioisotopic and potential antineoplastic…

Carbon C 13 Sodium Octanoate

The sodium salt form of the medium-chain fatty acid octanoate, and labeled with the isotope carbon C13, used in the octanoate breath…

Carbon C 13 Phytofluene

A 40-carbon hydrocarbon precursor of carotenoids radiolabeled to carbon C 13 and potentially used for tracer purposes of phytofluene in vivo. Upon…

Carbon C 13 Phytoene

A 40-carbon hydrocarbon precursor of carotenoids radiolabeled to carbon C 13 and potentially used for tracer purposes of phytoene in vivo. Upon…

Carbon C 13 Lycopene

Carbon C 13 labeled lycopene used as a tracer for carotenoid metabolism studies in vivo. After oral administration of carbon C 13…