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Carboxyamidotriazole
Pronunciation
Definition 1
An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors. (NCI Dictionary)
Definition 2
An orally-active agent with potential antineoplastic activity. Carboxyamidotriazole binds to and inhibits non-voltage-operated Ca2+ channels, blocking both Ca2+ influx into cells and Ca2+ release from intracellular stores and resulting in the disruption of calcium channel-mediated signal transduction and inhibition of vascular endothelial growth factor (VEGF) signaling, endothelial proliferation, and angiogenesis. This agent may also inhibit tumor cell growth, invasion and metastasis. (NCI Thesaurus)
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