Carcinoembryonic Antigen Peptide 1

Definition 1

A nine amino acid peptide fragment of carcinoembryonic antigen (CEA), a protein that is overexpressed in several cancer cell types, including gastrointestinal, breast, and non-small cell lung. Autologous vaccination with activated autologous dendritic cells (DC) or peripheral blood mononuclear cells (PBMC) which have been exposed to CEA peptide 1 in vitro may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing CEA, thereby inhibiting tumor growth. (NCI Thesaurus)

Definition 2

A small piece of a tumor marker called carcinoembryonic antigen (CEA). CEA may be found in the blood of people who have colon cancer, other types of cancer or diseases, or who smoke tobacco. Carcinoembryonic antigen peptide-1 is used to make a vaccine that may help stimulate the body's immune system to kill cancer cells. (NCI Dictionary)

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