Health / Medical Topics

    Carfilzomib

    Pronunciation

    Definition 1

    A drug used to treat multiple myeloma that has not gotten better with other anticancer drugs. It is also being studied in the treatment of other types of cancer. Carfilzomib blocks the action of enzymes called proteasomes, and may kill cancer cells. It is a type of proteasome inhibitor. Also called Kyprolis. (NCI Dictionary)

    Definition 2

    An epoxomicin derivate with potential antineoplastic activity. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S catalytic core subunit of the proteasome, a protease complex responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth. (NCI Thesaurus)




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