Caspase Activation

Caspase Activation involves induction of the activity of intracellular cysteine endopeptidase family members kept inactive by mitochondrial surface proteins (BcL-2 Family) and involved in initial signaling and downstream proteolytic cleavages (at P1 aspartic acids) in inflammation and apoptotic cell death when signals block BcL-2 function and activators initiate caspase cascades. (NCI Thesaurus)

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Caspase

Caspases are a family of intracellular cysteine proteinases involved in inflammation and apoptosis. These enzymes appear to be involved in the…

CASP9 wt Allele

Human CASP9 wild-type allele is located within 1p36.3-p36.1 and is approximately 32 kb in length. This allele, which encodes caspase-9 protein, is…

CASP9 Gene

This gene plays a role in the initiation of the apoptotic cascade.

CASP8*1 Allele

Human CASP8*1 allele is a variant form of the CASP8 gene which is located within 2q33-q34 and is approximately 54 kb in…

CASP8 wt Allele

Human CASP8 wild-type allele is located within 2q33-q34 and is approximately 54 kb in length. This allele, which encodes caspase-8 protein, plays…

CASP8 Gene

This gene is involved in apoptosis, immune cell homeostasis, lymphocyte activation and immunoprotection.