Health / Medical Topics |
CCND1/IGHG1 Fusion Gene
A fusion gene that results from a chromosomal translocation t(11;14)(q13;q32) which places the CCND1 gene on the 5' side of the joining segment of the immunoglobulin G heavy chain locus IGHG1 gene. This rearrangement is associated with numerous B-cell malignancies. (NCI Thesaurus)
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Human CCND1 wild-type allele is located within 11q13 and is approximately 13 kb in length. This allele, which encodes G1/S-specific cyclin-D1 protein,…
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