CCR2 Antagonist PF-04136309

An orally available human chemokine receptor 2 (CCR2) antagonist with potential immunomodulating and antineoplastic activities. Upon oral administration, CCR2 antagonist PF-04136309 specifically binds to CCR2 and prevents binding of the endothelium-derived chemokine ligand CLL2 (monocyte chemoattractant protein-1 or MCP1) to its receptor CCR2, which may result in inhibition of CCR2 activation and signal transduction. This may inhibit inflammatory processes as well as angiogenesis, tumor cell migration, and tumor cell proliferation. The G-protein coupled receptor CCR2 is expressed on the surface of monocytes and macrophages, stimulates the migration and infiltration of these cell types, and plays an important role in inflammation, angiogenesis, and tumor cell migration and proliferation. (NCI Thesaurus)

YOU MAY ALSO LIKE

CCR10 wt Allele

Human CCR10 wild-type allele is located within 17q21.1-q21.3 and is approximately 2 kb in length. This allele, which encodes C-C chemokine receptor…

CCR10 Gene

This gene is involved in the regulation of T cell-mediated inflammatory skin reactions and angiogenesis.

CCR1 wt Allele

Human CCR1 wild-type allele is located within 3p21 and is approximately 6 kb in length. This allele, which encodes C-C chemokine receptor…

CCR1 Gene

This gene is involved in immune cell mobilization to promote pro-inflammatory responses; further, the gene plays a role in chemotaxis.

CCNU

A drug used to treat brain tumors that have already been treated with surgery or radiation therapy. It is also used to…

CCNH wt Allele

Human CCNH wild-type allele is located within 5q13.3-q14 and is approximately 19 kb in length. This allele, which encodes cyclin-H protein, is…