CD19CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocytes

Autologous T-lymphocytes transduced with a modified lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) and the zeta chain of the TCR/CD3 complex (CD3-zeta), coupled to the signaling domain of 4-1BB (CD137), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD19CAR-CD3zeta-4-1BB-expressing autologous T-lymphocytes direct the T-lymphocytes to CD19-expressing tumor cells, thereby inducing a selective toxicity in CD19-expressing tumor cells. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19 and the inclusion of this signaling domain may increase the antitumor activity compared to the inclusion of the CD3-zeta chain alone. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD3-zeta (or CD247) is a transmembrane signaling adaptor polypeptide that regulates the assembly of complete TCR complexes and their expression on the cell surface. (NCI Thesaurus)

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Human CD19 wild-type allele is located in the vicinity of 16p11.2 and is approximately 7 kb in length. This allele, which encodes…

CD19 Gene

This gene plays a role in signal transduction and regulates the response of B cells to antigens.

CD19 Expressing Cell Count

The determination of the amount of the CD19 expressing cells in a sample.

CD19 Expressing B Cell Count

The determination of the number of CD19 expressing B cells present in a sample.