CD19CAR-CD3zeta-expressing Autologous T lymphocytes

Autologous T-lymphocytes transduced with a modified lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) and the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD19CAR-CD3zeta-expressing autologous T-lymphocytes are directed to CD19-expressing tumor cells, thereby inducing a selective toxicity only in these tumor cells. The CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD3-zeta (or CD247) is a transmembrane signaling adaptor polypeptide that regulates the assembly of complete T-cell receptor complexes and their expression on the cell surface. (NCI Thesaurus)

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Human CD19 wild-type allele is located in the vicinity of 16p11.2 and is approximately 7 kb in length. This allele, which encodes…

CD19 Gene

This gene plays a role in signal transduction and regulates the response of B cells to antigens.

CD19 Expressing Cell Count

The determination of the amount of the CD19 expressing cells in a sample.