CD33CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes

Autologous T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD33 scFv (single chain variable fragment) coupled to the signaling domain of 4-1BB (CD137) and the zeta chain of the T-cell receptor (TCRzeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD33-specific CAR retroviral vector-transduced autologous T lymphocytes target CD33-expressing tumor cells and induce selective toxicity in CD33-expressing tumor cells. Following binding to CD33, the 4-1BB co-stimulatory molecule signaling domain enhances both activation and signaling. Inclusion of the 4-1BB signaling domain may also increase the antitumor activity when compared to the inclusion of the CD3-zeta chain alone. CD33 is expressed on normal non-pluripotent hematopoietic stem cells as well as on myeloid leukemia cells. (NCI Thesaurus)

YOU MAY ALSO LIKE

CD33 wt Allele

Human CD33 wild-type allele is located in the vicinity of 19q13.3 and is approximately 15 kb in length. This allele, which encodes…

CD33 Gene

This gene is involved in both cell adhesion and cell-cell signaling.

CD33 Expressing Cell Count

The determination of the amount of CD33 expressing cells per unit present in a sample.

CD31 Antigen

CD31 antigen (738 aa, 83 kD) is a cell communication protein that is encoded by the human PECAM1 gene and has a…

CD30-Positive Neoplastic Cells Present

A finding that a sample of neoplastic cells has detectable immunoreactivity for CD30 (TNFRSF8).

CD30 Immunotoxin

An immunotoxin composed of an anti-CD30 monoclonal antibody and a toxin moiety, which targets antigen-positive cells and causes cytotoxic activity.