CD3 Complex

Consisting of cell surface type I membrane Delta, Epsilon, Gamma, Zeta, and Eta protein subunits with ITAM domains and noncovalently associated with the disulfide bound heterodimeric alpha/beta and gamma/delta TCR, the CD3 complex couples receptor antigen recognition to signal transduction pathways during T-cell activation. During TCR engagement with MHC-associated antigen on host cell surfaces and synapse formation, CD3 activity leads to Tyr-phosphorylated CD3 subunits, Tyr phosphorylation of LAT colocalized in lipid rafts, and MAPK activation. CD3 signal transduction appears to involve LCK, ZAP70, Nck, SLA, SLA2, and DOCK2. CD3 subunits may also associate with the cytoskeleton. CD3 also mediates TCR signal transduction during the developmental transition through positive selection of immature thymocytes to mature CD4+ or CD8+ T cells. (NCI Thesaurus)

YOU MAY ALSO LIKE

CD3 Cell to Lymphocyte Ratio Measurement

The determination of the ratio of CD3 cells compared to lymphocytes present in a sample. The measurement may be expressed as a…

CD2AP wt Allele

Human CD2AP wild-type allele is located in the vicinity of 6p12 and is approximately 150 kb in length. This allele, which encodes…

CD2AP Gene

This gene plays a role in both protein-protein interactions and cell division.

CD28 wt Allele

Human CD28 wild-type allele is located within 2q33 and is approximately 31 kb in length. This allele, which encodes T-cell-specific surface glycoprotein…

CD28 Gene

This gene plays several roles in cellular functions specific to the T-cell.

CD276 wt Allele

The CD276 wild-type allele is located within 15q23-q24 and is approximately 30 kb in length. This allele, which encodes CD276 antigen protein,…