| Health / Medical Topics |
CD40 Ligand Deficiency
Patients with the X-linked hyper IgM syndrome have a deficiency of a protein, CD40 ligand that is found on the surface of T-lymphocytes. As a consequence of the deficiency of this protein, their T-lymphocytes are unable to instruct B-lymphocytes to switch their production of gamma globulins from IgM to IgG and IgA. As a result, patients have decreased levels of IgG and IgA and normal or elevated levels of IgM. In addition, since CD40 ligand is important to other functions of T-lymphocytes, they also have a defect in some of the protective functions of their T-lymphocytes. (NCI Thesaurus)
YOU MAY ALSO LIKE
CD40 ligand (261 aa, 29 kD) is a cellular division process protein that is encoded by the human CD40LG gene and has…
This gene is involved in the regulation of apoptosis, inflammatory responses, and immune responses.
A fully human monoclonal antibody (mAb) agonist of the cell surface receptor CD40 with potential immunostimulatory and antineoplastic activities. Similar to the…
Regulatory T cells that express CD4 and CD25 (interleukin 2 receptor) antigens, with immunomodulating activity. CD4+CD25+ T regulatory cells (Tregs), a subset…
A type of white blood cell that helps stimulate immune system reactions. Helper T cells help activate cytotoxic T cells and…
A type of immune cell that stimulates killer T cells, macrophages, and B cells to make immune responses. A CD4-positive T lymphocyte…
