| Health / Medical Topics |
CDC25 and CHK1 Regulatory Pathway
Cdc25 is a protein phosphatase responsible for dephosphorylating and activating cdc2, a crucial step in regulating the entry of all eukaryotic cells into the M-phase of the cell cycle. Cdc25 is phosphorylated throughout interphase but not in mitosis. The primary site for phosphorylation of cdc25 is Ser216. Phosphorylated cdc25 binds to members of the 14-3-3 family of proteins which prevents its activation of cdc2. Chk1, a protein kinase involved in the DNA damage checkpoint response in fission yeast, has been shown to phosphorylate cdc25 at Ser216 in vitro. (NCI Thesaurus/BIOCARTA)
YOU MAY ALSO LIKE
Human CDC20 wild-type allele is located in the vicinity of 1p34.1 and is approximately 4 kb in length. This allele, which encodes…
This gene plays a role in cell cycle progression.
A logarithmic scheme for reporting the quantitation of Mycobacterium infection.
A U.S. federal government agency whose mission is to protect public health by preventing and controlling disease, injury, and disability. The CDC…
Human CDAN1 wild-type allele is located in the vicinity of 15q15.2 and is approximately 14 kb in length. This allele, which encodes…
This gene may be involved in nuclear membrane maintenance.
