CDC7 Kinase Inhibitor BMS-863233

An orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. CDC7 kinase inhibitor BMS-863233 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. CDC7, a serine-threonine kinase overexpressed in a variety of tumor cell types, plays an essential role in the initiation of DNA replication by activating origins of replication. (NCI Thesaurus)

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CDC7 Gene

This gene is involved in the initiation of DNA replication and inhibition of cell proliferation. It also plays a putative role in…

CDC6 wt Allele

Human CDC6 wild-type allele is located in the vicinity of 17q21.3 and is approximately 15 kb in length. This allele, which encodes…

CDC6 Gene

This gene plays a role in regulation of the early steps of DNA replication.

CDC45L wt Allele

Human CDC45L wild-type allele is located in the vicinity of 22q11.21 and is approximately 41 kb in length. This allele, which encodes…

CDC45L Gene

This gene plays a role in the initiation of DNA replication.

CDC45-Related Protein

CDC45-related protein (566 aa, ~66 kDa) is encoded by the human CDC45L gene. This protein is involved in the initiation of genomic…