Cephalostatin

The cephalostatins comprise a family of more than 30 trisdecacyclic bissteroidal pyrazines with extreme cytotoxicity against human tumors, isolated from the African marine worm Cephalodiscus gilchristi. The mechanism of action of these compounds remains unknown. Beside a steroidal platform, critical features implicated in the pharmacophore include a set of covalently linked polar and nonpolar domains and the spiroketals. It was shown that cephalostatin 1 induces a novel pathway of receptor-independent apoptosis that selectively uses Smac/DIABLO (second mitochondria-derived activator of caspases/direct inhibitor of apoptosis-binding protein with a low isoelectric point) as a mitochondrial signaling molecule. Apoptosis was found to be dependent on caspase activity because the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone blocks cephalostatin 1-mediated DNA fragmentation. (NCI Thesaurus)

YOU MAY ALSO LIKE

Cephalosporin Antibiotic

A synthetic or semi-synthetic beta-lactam antibiotic derived from Acremonium (Cephalosporium) fungi with bactericidal activity. Cephalosporin antibiotics bind to and inactivate penicillin-binding proteins…

Cephalosporin

A drug used to treat bacterial infections. It belongs to the family of drugs called antibiotics.

Cephaloridine

A semisynthetic, broad-spectrum, first-generation cephalosporin with antibacterial activity. Cephaloridine binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of…

Cephalomannine

A diterpene taxane obtained from the bark and leaves of the yew tree (Taxus brevifolia) and can convert to taxol.

Cephaloglycin Anhydrous

The anhydrous form of cephaloglycin, a semisynthetic first-generation cephalosporin with antibacterial activity. Cephaloglycin binds to and inactivates penicillin-binding proteins (PBPs) located on…

Cephaloglycin

A semisynthetic first-generation cephalosporin with antibacterial activity. Cephaloglycin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the…