CHEK2 wt Allele

Human CHEK2 wild-type allele is located in the vicinity of 22q12.1 and is approximately 57 kb in length. This allele, which encodes serine/threonine-protein kinase Chk2 protein, is involved in prevention of entry into mitosis and induction of G1 checkpoint arrest in response to DNA damage. Certain allelic variants of the CHEK2 gene that encode protein products with reduced or abolished activity are associated with Li-Fraumeni syndrome 2. Heritable alterations in this gene also confer susceptibility to breast, colorectal and prostate cancers. (NCI Thesaurus)

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This gene plays a role in cell survival and the negative regulation of cell growth.

CHEK1 wt Allele

Human CHEK1 wild-type allele is located within 11q24-q24 and is approximately 29 kb in length. This allele, which encodes serine/threonine-protein kinase Chk1…

CHEK1 Gene

This gene is involved in the negative regulation of cell growth.

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An inflammatory process affecting the lip.

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A surgical procedure used to remove bone spurs or irregularities from a joint.

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