Chemokine (C Motif) Ligand 2

Expressed, like XCL1, in activated T cells (low levels in unstimulated cells) by human XCL2 Gene (Intercrine Gamma Family), 114-aa 12.5-kDa (precursor) secreted Chemokine (C Motif) Ligand 2 is most homologous to CCL8 and CCL3 chemokines, but lacks the first and third cysteines characteristic of CC and CXC chemokines and is chemotactic for lymphocytes, but not for monocytes or neutrophils. XCL2 differs from XCL1 (a separate gene product) by only 2 amino acids; XCL2 encodes His7 and Arg8 (mature protein) instead of Asp and Lys as in XCL1. XCL2 induces migration of cells expressing XCR1. Small (8-14 kD), mostly basic, chemokines interact with 7-transmembrane G protein-coupled receptors and regulate cell trafficking of leukocytes, as well as development, homeostasis, and immune system function. (NCI Thesaurus)

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