| Library / English Dictionary |
CLEAVABLE
| Pronunciation (US): |  | (GB): | |
I. (adjective)
Sense 1
Meaning:
Capable of being cleaved
Classified under:
Similar:
divisible (capable of being or liable to be divided or separated)
Context examples:
The cathepsin-activatable fluorescent probe LUM015 contains the Cy5 fluorophore linked, via a pan-cathepsin protease cleavable peptide, to a fluorescent quencher.
(Cathepsin-Activatable Cy5 Fluorescent Imaging Probe LUM015, NCI Thesaurus)
Cositecan stabilizes the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks and consequently triggering apoptosis.
(Cositecan, NCI Thesaurus)
An immunoconjugate consisting of a human monoclonal antibody directed against the deletion-mutant of epidermal growth factor receptor, EGFRvIII, conjugated via a non-cleavable linker to the cytotoxic agent maytansinoid DM1, with potential antineoplastic activity.
(Anti-EGFRvIII Antibody Drug Conjugate AMG 595, NCI Thesaurus)
An immunoconjugate consisting of the humanized monoclonal antibody M9346A against folate receptor 1 (FOLR1) conjugated, via the disulfide-containing cleavable linker sulfo-SPDB, to the cytotoxic maytansinoid DM4, with potential antineoplastic activity.
(Anti-FOLR1-Monoclonal Antibody-Maytansinoid Conjugate IMGN853, NCI Thesaurus)
An immunoconjugate consisting of a human IgG1 monoclonal antibody directed against CD27L conjugated, via a non-cleavable linker, to the cytotoxic agent maytansinoid DM1, with potential antineoplastic activity.
(Anti-CD27L Antibody-Drug Conjugate AMG 172, NCI Thesaurus)
Compared to reducible, cleavable linkers, the non-reducible SMCC linker shows increased stability in plasma.
(Anti-CD37 Antibody-Drug Conjugate IMGN529, NCI Thesaurus)
As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis.
(Elliptinium, NCI Thesaurus)
An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against B-cell antigen receptor complex-associated protein beta chain (CD79B) conjugated, via a protease-cleavable peptide linker, to monomethyl auristatin E (MMAE), an auristatin derivative and a potent microtubule inhibitor, with potential antineoplastic activity.
(Anti-CD79B Monoclonal Antibody-MMAE Conjugate DCDS4501A, NCI Thesaurus)
An antibody drug conjugate (ADC) consisting of a humanized IgG1 monoclonal antibody targeting the MUC16 protein (CA-125) conjugated to, via a cleavable linker, the antimicrotubulin agent monomethyl auristatin E (MMAE), with potential antineoplastic activity.
(MUC16-targeted Antibody-Drug Conjugate DMUC5754A, NCI Thesaurus)
An antibody-drug conjugate (ADC) composed of MCDT2219A , a humanized IgG1 anti-CD22 monoclonal antibody covalently linked, via a protease-cleavable peptide linker, to monomethyl auristatin E (MMAE), an auristatin derivative and a potent microtubule disrupting agent ,with potential antineoplastic activity.
(Anti-CD22 Monoclonal Antibody-MMAE Conjugate DCDT2980S, NCI Thesaurus)
