Clofarabine

Pronunciation

Definition 1

A drug used to treat certain types of acute lymphoblastic leukemia in children. It is also being studied in the treatment of other types of cancer. Clofarabine is a type of nucleoside analog. Also called Clolar. (NCI Dictionary)

Definition 2

A second generation purine nucleoside analog with antineoplastic activity. Clofarabine is phosphorylated intracellularly to the cytotoxic active 5'-triphosphate metabolite, which inhibits the enzymatic activities of ribonucleotide reductase and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of pre-apoptotic factors, including cytochrome C and apoptotic-inducing factors, which activate apoptosis. (NCI Thesaurus)

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Clockwise

Circular movement in the direction of the rotation of the hands of a clock.

Clockface or Region

A location identifier based on clockface numbering or anatomic subregion.