| Health / Medical Topics |
Collagen IV (Alpha 6)
Collagen IV (Alpha 6), encoded by the human COL4A6 gene, is a subunit of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Two splice variants have been identified for this gene. (From LocusLink and NCI) (NCI Thesaurus)
YOU MAY ALSO LIKE
Collagen IV (Alpha 3),encoded by the human COL4A3 gene, is a subunit of type IV collagen, the major structural component of basement…
The major structural component of basement membranes, Collagen-IV consists of six subunits encoded by genes COL4A1, COL4A2, COL4A3, COL4A4, COL4A5 and…
Collagen I (Alpha 2), encoded by the COL1A2 gene, is one of the chains for type I collagen, the fibrillar collagen found…
Collagen I (Alpha 1), encoded by the COL1A1 gene, is the major component of type I collagen, the fibrillar collagen found in…
Collagen Genes encode different forms of Collagen, the principle fibrous protein of connective tissue, all consisting of triple helix alpha-polypeptide chains. Collagen…
A term previously used to describe chronic diseases of the connective tissue (e.g., rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis), but…
