Collecting Duct Acid Secretion Pathway

One of the important roles of the collecting duct segment of the kidney nephron is acid secretion. As daily food intake loads acid into the body, urinary acid excretion is essential, and urine pH can drop as low as 4.5. The alpha-intercalated cell of collecting duct is the main responsible for hydrogen secretion into the urine. The carbon dioxide, which is generated in the cells and enters from the blood, is changed to carbonic acid. This carbonic acid is divided into hydrogen ion and bicarbonate ion. Intracellular CA II catalyses the formation of these ions. The hydrogen ion is secreted into the lumen by the luminal H(+)-ATPase. The bicarbonate ion is transported to the blood side by the anion exchanger type 1. Hydrogen ion in the lumen is trapped by urinary buffers. These include ammonium and phosphate. (NCI Thesaurus/KEGG)

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Collecting duct

The last part of a long, twisting tube that collects urine from the nephrons (cellular structures in the kidney that filter blood…

Collecting Cell

A simple cuboidal epithelial cell lining the collecting duct of the kidney. Its function is dependent upon its location on the collecting…

Collected By

Indicates the person, group, or institution who performed the collection act.

Collected

Collected refers to objects having been brought together in one place.

Collateral Gyrus

The convolutions or ridges on either side of the collateral sulcus.

Collateral Fissure

A long deep groove on the tentorial surface below the posterior and descending horns of the lateral ventricle which extends from the…