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Colony Stimulating Factor 1
Definition 1
Synthesized by mesenchymal cells, Macrophage Colony-Stimulating Factor is a 70 kD disulfide-bonded homodimeric glycoprotein cytokine that binds to FMS (a specific high affinity receptor) and stimulates survival, proliferation, and differentiation of committed hematopoietic cells of the related granulocyte and monocyte-macrophage lineages. Three isoforms of M-CSF result from alternative splicing. The active forms may be produced by proteolytic cleavage; precursors may exist as integral membrane proteins. Isoform 1 may undergo rapid proteolytic cleavage to yield an extracellular growth factor. Isoform 3 may exist as an integral membrane protein that undergoes slow proteolysis at the cell surface to yield a soluble growth factor. (from OMIM 120420, SWISS-PROT P09603, and NCI) (NCI Thesaurus)
Definition 2
This protein is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. It may also be involved in development of the placenta. (NCI Thesaurus/LocusLink)
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