| Health / Medical Topics |
Colony Stimulating Factor 2 Receptor Alpha Chain
Expressed as alternative membrane-bound and soluble isoforms (3, 4, and 6) by human CSF2RA Gene (Type I Cytokine Receptor 5 Family), Colony Stimulating Factor 2 Receptor Alpha Chain is a type I membrane protein with a box 1 motif for JAK interaction/activation; a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding; and the alpha subunit of a heterodimeric low affinity receptor for granulocyte-macrophage colony-stimulating factor. The receptor signal transducing beta chain is common to the IL3-, IL5- and GM-CSF receptors. CSF2R transduces the CSF2 signal for proliferation, differentiation, and activation of (primarily) granulocyte and macrophage hematopoietic cells. (NCI Thesaurus)
YOU MAY ALSO LIKE
An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory…
Synthesized by mesenchymal cells, Macrophage Colony-Stimulating Factor is a 70 kD disulfide-bonded homodimeric glycoprotein cytokine that binds to FMS (a specific high…
A substance that stimulates the production of blood cells. Colony-stimulating factors include granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and…
A multi-user relational database management system for managing animal colonies in a research environment.
A unit of cell concentration expressed as the number of viable cells per million total cells.
A derived unit of measurement of viable bacterial organisms in a unit volume of substance of interest defined as the number of…
