| Health / Medical Topics |
Combined Epithelial / Stromal Atypical Hyperplasia of the Mouse Prostate Gland
Definition 1
Herniating or protruding into periprostatic fat needs to be distinguished from true invasion. (NCI Thesaurus/MMHCC)
Definition 2
Implies there is proliferation of both epithelial and stromal components; whether cytologic atypia is present in epithelium, stroma, or both should be described. (NCI Thesaurus/MMHCC)
Definition 3
Lesions referred to as "papilloma" or "phylloides-like" tumor often occuring in background of more widespread epithelial hyperplasia should currently be classified as hyperplasias, with or without atypia. (NCI Thesaurus/MMHCC)
Definition 4
Phylloides-like lesions, referring to resemblance to human neoplasm most characteristic in breast, typically seen against background of more widespread atypical epithelial +/- stromal proliferation, as opposed to a distinct focal neoplasm against normal prostate background. Such lesions in TRAMP and LPB-Tag mice noted against background meeting criteria for HGPIN, as noted below. (NCI Thesaurus/MMHCC)
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