Comparative Genomic Hybridization

Definition 1

Comparative genomic hybridization (CGH) is a technique that allows the detection of losses and gains in DNA copy number across the entire genome without prior knowledge of specific chromosomal abnormalities. Comparative genomic hybridization utilizes the hybridization of differentially labeled tumor and reference DNA to generate a map of DNA copy number changes in tumor genomes. Comparative genomic hybridization is an ideal tool for analyzing chromosomal imbalances in archived tumor material and for examining possible correlations between these findings and tumor phenotypes. (from Ried et al. J Mol Med 1997 75:801-14) (NCI Thesaurus)

Definition 2

technique which produces a map of DNA sequence copy number as a function of chromosomal location throughout the entire genetic genome, and allows the detection of genetic deletions, duplications, and amplifications. (NIH CRISP Thesaurus)

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