Connective Tissue-Activating Peptide III

Encoded by human PPBP Gene (Alpha Chemokine CXC Family), secreted 128-aa 14-kDa (precursor) Pro-Platelet Basic Protein is a platelet-derived growth factor that is processed to PBP and Connective-Tissue-Activating_Peptide-III. Proteolytic removal of PPBP residues 1-9 produces active peptide CTAP-III/LA-PF4, which stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan, as well as formation and secretion of plasminogen activator. Upon platelet activation, PBP is proteolytically converted to beta thromboglobulin, a homotetramer released when platelets aggregate; CTAP-III is proteolytically converted to NAP2, a potent chemoattractant and activator of neutrophils. (NCI Thesaurus)

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