Cortactin

Encoded by human EMS1 Gene, 550-amino acid Cortactin is an actin-binding protein involved in restructuring of the cortical actin cytoskeleton. Similar to murine Cttn, cytoplasmic Cortactin is located in cell-substratum contact areas and contains one SH3 domain that may bind to the cytoskeleton. Cortactin may organize epithelial cell structure; it regulates interactions between adherens junction components and interacts with the cytoskeleton. It may interact with SHANK2 and SHANK3 via its SH2 domain. A substrate for pp60v-SRC, Cortactin tyrosine phosphorylation may regulate cell growth. EGF enhances p85 phosphorylation and causes p80 to p85 conversion. Posttranslational modification of Cortactin coincides with redistribution to cell-matrix contact sites. Cortactin is degraded during apoptosis in a caspase-dependent manner. (from Swiss-Prot, OMIM, and NCI) (NCI Thesaurus)

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