Cortisporin Formulation

A combination preparation containing the polypeptide antibiotic polymyxin b, the aminoglycoside antibiotic neomycin, the glucocorticoid hydrocortisone and, in some formulations, the antibiotic bacitracin zinc with antibacterial and anti-inflammatory activities. Polymyxin B, neomycin and bacitracin zinc exert antibacterial effects through a cationic detergent-like action on cell membranes, inhibition of protein synthesis, and inhibition of peptidoglycan synthesis, respectively. Hydrocortisone initially binds to the cytoplasmic glucocorticoid receptor; then the receptor-ligand complex is translocated to the nucleus where it initiates the transcription of genes encoding for anti-inflammatory mediators, such as cytokines and lipocortins. (NCI Thesaurus)

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The determination of the ratio of cortisol compared to creatinine present in a sample. The measurement may be expressed as a ratio…

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The determination of the amount of cortisol present in a sample.

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