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Cositecan
Definition 1
A synthetic silicon-containing agent related to camptothecin with antineoplastic properties. Cositecan stabilizes the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks and consequently triggering apoptosis. Because it is lipophilic, cositecan exhibits enhanced tissue penetration and bio-availability compared to water-soluble camptothecins. (NCI Thesaurus)
Definition 2
A drug being studied in the treatment of cancer. It belongs to a family of drugs called topoisomerase inhibitors. It is related to the anticancer drug camptothecin. (NCI Dictionary)
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