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COX
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
The helmsman of a ship's boat or a racing crew
Synonyms:
cox; coxswain
Classified under:
Hypernyms ("cox" is a kind of...):
helmsman; steerer; steersman (the person who steers a ship)
Derivation:
cox (act as the coxswain, in a boat race)
Sense 2
Meaning:
Either of two related enzymes that control the production of prostaglandins and are blocked by aspirin
Synonyms:
Cox; cyclooxygenase
Classified under:
Hypernyms ("Cox" is a kind of...):
enzyme (any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions)
Hyponyms (each of the following is a kind of "Cox"):
Cox-1; cyclooxygenase-1 (an enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys)
Cox-2; cyclooxygenase-2 (an enzyme that makes prostaglandins that cause inflammation and pain and fever)
II. (verb)
Sense 1
Meaning:
Act as the coxswain, in a boat race
Classified under:
Verbs of political and social activities and events
Hypernyms (to "cox" is one way to...):
be; follow (work in a specific place, with a specific subject, or in a specific function)
Sentence frame:
Somebody ----s
Derivation:
cox (the helmsman of a ship's boat or a racing crew)
Context examples:
The Coxes were wondering last night whether she would get into any great family.
(Emma, by Jane Austen)
Cox-1 is expressed in a constitutive manner throughout most tissues, and plays an essential role in maintaining the integrity of the stomach mucosal lining.
(Acetaminophen Pathway, NCI Thesaurus/BIOCARTA)
How did you think the Coxes looked?
(Emma, by Jane Austen)
A novel Cox enzyme isoform encoded by the Cox-1 gene, Cox-3, contains an additional 30-34 amino acids and is expressed selectively in the brain.
(Acetaminophen Pathway, NCI Thesaurus/BIOCARTA)
Oh! They talked a great deal about him, especially Anne Cox.
(Emma, by Jane Austen)
This insertion alters the pharmacology of the Cox enzyme, making Cox-3 sensitive to selective inhibition by acetaminophen and other drugs that reduce pain and fever but have weak anti-inflammatory activity, explaining the pharmacology of these drugs.
(Acetaminophen Pathway, NCI Thesaurus/BIOCARTA)
Miss Nash thinks either of the Coxes would be very glad to marry him.
(Emma, by Jane Austen)
While these two isoforms were sufficient to account for most NSAIDs pharmacology, the actions of acetaminophen remained hard to explain on the basis of inhibiting Cox-1 and Cox-2 alone, such as its efficacy at reducing pain and fever but lack of anti-inflammatory effects.
(Acetaminophen Pathway, NCI Thesaurus/BIOCARTA)
She meant to be impertinently curious, just as such an Anne Cox should be.
(Emma, by Jane Austen)
A word was put in for a second young Cox; and at last, Mr. Weston naming one family of cousins who must be included, and another of very old acquaintance who could not be left out, it became a certainty that the five couple would be at least ten, and a very interesting speculation in what possible manner they could be disposed of.
(Emma, by Jane Austen)
