CpG Oligodeoxynucleotide GNKG168

A synthetic, 21-mer, unmethylated CpG motif-based oligodeoxynucleotide (ODN), with immunostimulatory activity. CpG oligodeoxynucleotide GNKG168 binds to and activates Toll-like receptor 9 (TLR9) and is taken up into cells by endocytosis; once internalized, it may activate numerous signaling transduction pathways resulting in the release of multiple cytokines, such as immunoglobulins (Igs), interferons (IFNs), interleukins (ILs) and tumor necrosis factor (TNF). Through activation of TLR9, this ODN can directly stimulate B-lymphocytes, dendritic and natural killer (NK) cells, resulting in an increase in innate immunity and antibody-dependent cellular cytotoxicity (ADCC). In addition, through the release of IL-12 and IFN, this agent may induce a preferential shift to the T-helper 1(Th1) phenotype resulting in enhanced CD8+ T cell-mediated antitumor cytotoxicity. (NCI Thesaurus)

YOU MAY ALSO LIKE

CpG Island Methylator Phenotype

A phenotype whereby a subset of tumors are characterized by the simultaneous hypermethylation of multiple promoter-associated CpG islands.

CpG Island

Short region of DNA in which the frequency of the CG sequence is higher than in other regions.

CpG Dinucleotide

A dinucleotide consisting of cytosine followed by guanine.

CpG Antibody

Any immunoglobulin that recognizes cytosine/guanine (CpG) rich sequences in chromosomal DNA.

CpG 7909

A substance that is being studied in the treatment of some types of cancer. It belongs to the family of drugs called…

CPE wt Allele

Human CPE wild-type allele is located in the vicinity of 4q32.3 and is approximately 120 kb in length. This allele, which encodes…