| Library / English Dictionary |
CRUCIAL
| Pronunciation (US): |  | (GB): | |
I. (adjective)
Sense 1
Meaning:
Of extreme importance; vital to the resolution of a crisis
Example:
a crucial issue for women
Synonyms:
crucial; important
Classified under:
Similar:
critical; decisive (forming or having the nature of a turning point or crisis)
life-and-death; life-or-death (vitally important)
pivotal; polar (being of crucial importance)
Also:
critical (being in or verging on a state of crisis or emergency)
decisive (determining or having the power to determine an outcome)
essential (basic and fundamental)
Antonym:
noncrucial (of little importance; not decisive)
Derivation:
cruciality (a state of critical urgency)
Sense 2
Meaning:
Of the greatest importance
Example:
in chess cool nerves are of the essence
Synonyms:
all-important; all important; crucial; essential; of the essence
Classified under:
Similar:
important; of import (of great significance or value)
Derivation:
cruciality (a state of critical urgency)
Sense 3
Meaning:
Having crucial relevance
Example:
relevant testimony
Classified under:
Adjectives
Similar:
material (directly relevant to a matter especially a law case)
Context examples:
Specific haematopoietic transcription factors are crucial for differentiation to particular lineages during normal differentiation, but are frequently disrupted in AML.
(Acute Myeloid Leukemia Pathway, NCI Thesaurus/KEGG)
The receptor tyrosine kinases VEGFR2, PDGFRb and EphB4 may be overexpressed in a number of different cancer cell types and may play crucial roles in tumor angiogenesis.
(Angiogenesis Inhibitor JI-101, NCI Thesaurus)
Alpha5beta1 integrin, a cell adhesion and signaling receptor, is often overexpressed on the surface of tumor vessel endothelial cells and plays a crucial role in endothelial cell adhesion and migration.
(Anti-A5B1 Integrin Monoclonal Antibody PF-04605412, NCI Thesaurus)
Those are the crucial points upon which the case depends.
(The Adventures of Sherlock Holmes, by Sir Arthur Conan Doyle)
AlphaVbeta3 integrin, a cell adhesion and signaling receptor, is expressed on the surface of tumor vessel endothelial cells and plays a crucial role in endothelial cell adhesion and migration.
(Anti-alphaVbeta3 Monoclonal Antibody EMD 525797, NCI Thesaurus)
GDF9 is crucial for normal ovarian folliculogenesis and female fertility.
(Growth Differentiation Factor 9, NCI Thesaurus)
The Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and organs.
(Hedgehog Signaling Pathway, NCI Thesaurus/KEGG)
They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification.
(Peroxisome Biogenesis Pathway, NCI Thesaurus/KEGG)
This prevents the synthesis of ergosterol which is a crucial component of the fungal cell membrane.
(Parconazole, NCI Thesaurus)
PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.
(PI3K Inhibitor GSK1059615, NCI Thesaurus)
