CTCAE Grade 2 Anus Fistula

Symptomatic; altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids indicated <24 hrs (NCI Thesaurus/CTCAE)

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CTCAE Grade 2 Anorexia

Oral intake altered without significant weight loss or malnutrition; oral nutritional supplements indicated

CTCAE Grade 2 Anal Sphincter Intra-Operative Injury

Partial resection of injured organ/structure indicated

CTCAE Grade 2 Anal or Perianal Infection with Unknown Absolute Neutrophil Count

Localized, local intervention indicated

CTCAE Grade 2 Anal or Perianal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils

Localized, local intervention indicated

CTCAE Grade 2 Anal or Perianal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils

Localized, local intervention indicated

CTCAE Grade 2 Anal Incontinence

Daily use of pads required