CTCAE Grade 2 Cytokine Release Syndrome or Acute Infusion Reaction

Requires therapy or infusion interruption but responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics, IV fluids); prophylactic medications indicated for <=24 hrs (NCI Thesaurus/CTCAE)

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CTCAE Grade 2 Cystitis

Frequency with dysuria; macroscopic hematuria

CTCAE Grade 2 Cushingoid Appearance

CTCAE Grade 2 Creatinine

1.5 - 3.0 x ULN

CTCAE Grade 2 Creatine Phosphokinase

2.5 x ULN - 5 x ULN

CTCAE Grade 2 Cranial Nerve XII Neuropathy

Symptomatic, not interfering with ADL

CTCAE Grade 2 Cranial Nerve XII Intra-Operative Injury

Partial resection of injured organ/structure indicated