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CTCAE Grade 2 Delayed Puberty
No breast development by age 13 yrs for females; no Tanner Stage 2 development by age 14.5 yrs for males (NCI Thesaurus/CTCAE)
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IV fluids indicated <24 hrs
Requires therapy or infusion interruption but responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics, IV fluids); prophylactic medications indicated for <=24…
Frequency with dysuria; macroscopic hematuria
1.5 - 3.0 x ULN
2.5 x ULN - 5 x ULN
