CTCAE Grade 2 Fibrosis-Deep Connective Tissue

Increased density with firmness or tethering (NCI Thesaurus/CTCAE)

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CTCAE Grade 2 Fibrosis-Cosmesis

Readily apparent but not disfiguring

CTCAE Grade 2 Fibrinogen

<0.75 - 0.5 x LLN or 25 - <50% decrease from baseline

CTCAE Grade 2 Fever Without Neutropenia

39.0 - 40.0 degrees C (102.3 - 104.0 degrees F)

CTCAE Grade 2 FEV1

<75 - 50% of predicted value

CTCAE Grade 2 Female Genital Tract Fistula

Symptomatic; noninvasive intervention indicated

CTCAE Grade 2 Fatigue

Moderate or causing difficulty performing some ADL