CTCAE Grade 2 Hypertension

Recurrent or persistent (>=24 hrs) or symptomatic increase by >20 mmHg (diastolic) or to >150/100 if previously WNL; monotherapy may be indicated Pediatric: Recurrent or persistent (>=24 hrs) BP >ULN; monotherapy may be indicated (NCI Thesaurus/CTCAE)

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CTCAE Grade 2 Hyperpigmentation

Marked or generalized

CTCAE Grade 2 Hyperbilirubinemia

1.5 - 3.0 x ULN

CTCAE Grade 2 Hydrocephalus

Mild to moderate symptoms not interfering with ADL

CTCAE Grade 2 Hot Flashes or Flushes

CTCAE Grade 2 Hiccoughs

Symptomatic, intervention indicated

CTCAE Grade 2 Hepatic Vein Intra-Operative Injury

Partial resection of injured organ/structure indicated