CTCAE Grade 2 Hypopigmentation

Recurrent or persistent (>=24 hrs) or symptomatic increase by >20 mmHg (diastolic) or to >150/100 if previously WNL; monotherapy may be indicated…

Marked or generalized

1.5 - 3.0 x ULN

Mild to moderate symptoms not interfering with ADL

Symptomatic, intervention indicated